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Intracerebral SB623 implantation in patients with chronic ischemic stroke demonstrated safety and a clinical signal in a phase 1/2a study, supporting a local trophic/plasticity mechanism [41]
Transgenic mice in which GCLC expression is abolished in hepatocytes have 58% of normal hepatic GSH levels and manifest liver pathologies characteristic of the various clinical stages of fatty liver disease 8,9
The buzziest use case is CagriSema, which pairs cagrilintide with the GLP-1 drug semaglutide for a potential one-two punch on appetite
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