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The expression of DMT1 is significantly increased in the substantia nigra of PD patients, resulting in enhanced cellular uptake of Fe 2+
It is also used off-label for male erectile dysfunction
It is still in very early preclinical research and is not available as a treatment
The TPH2 gene is located on chromosome 12q21.1 and is composed of 13 exons that encode a protein (tryptophan 5-hydroxylase 2) of 490 amino acids
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