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The aortic valve can become stiffened and calcified as we age so it can struggle to open and close properly, meaning the heart must work much harder to pump against a stiff valve, this is called aortic stenosis

Higher concentrations may offer some stability advantages in certain formulations because the peptide-to-surface ratio is more favorable, but they can also increase the risk of aggregation if the formulation is not optimized for that concentration

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Most people start noticing subtle changes within a few days to weeks, though the timeline varies depending on your starting health status, lifestyle, and treatment frequency