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Three pilot studies with very small sample sizes, a Phase II trial whose results remain unpublished, and a regulatory record that reflects the FDA's own assessment that sufficient human safety data do not exist that is the complete ledger as of 2025

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There was a discrepancy between the previous results and the results of a meta-analysis, which demonstrated no significant effect of L-carnitine on all-cause mortality or major cardiac events, including heart failure, unstable angina, and myocardial reinfarction