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According to FDA prescribing information, the most frequently reported adverse reactions include: Gastrointestinal symptoms: Nausea (24-30% of patients) often most pronounced after dose increases Vomiting (8-12% of patients) typically occurs when nausea is severe or unmanaged Diarrhea (18-24% of patients) can range from mild to moderate in severity Constipation (16-17% of patients) paradoxically occurs alongside diarrhea in some individuals Abdominal pain or discomfort (10-14% of patients) often described as cramping or bloating Dyspepsia (6-9% of patients) indigestion, heartburn, or upper abdominal discomfort Gastroesophageal reflux disease (5-7% of patients) Eructation (belching) (5-7% of patients) These symptoms frequently overlap and compound one another
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Tiredness may occur when starting semaglutide treatment and during upward dose adjustments
Tirzepatide is not appropriate for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
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