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Hypothalamic tanycytes are glial cells located along the walls and floor of the third ventricle, which are known to play neuroendocrine roles such as detecting and transporting nutrients and hormones like insulin and GLP-1, as well as regulating neuronal activity [60-62]
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Tirzepatide (Zepbound / Mounjaro) Tirzepatide activates both GLP-1 and GIP receptors simultaneously a dual mechanism that produces significantly greater weight loss than GLP-1 alone
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