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Between late 2023 and 2024, the FDA moved several popular peptides to the Category 2 list, citing concerns about insufficient human safety data and the potential for immunogenicity (the property of provoking an immune response)

Any other use is strictly forbidden

However, the most important advantage is the very safe profile of BPC (the lethal dose (LD1) could be not achieved) ( in situ hybridization and immunostaining for BPC 157 in the human gastrointestinal mucosa, lung bronchial epithelium, the epidermal layer of the skin, and kidney glomeruli) (Xu et al., 2020)

Spirulina samples grown in water contaminated with heavy metals have been reported to reduce protein content and impair nutritional quality