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The most significant published data comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al
These are included to enhance the liver-supporting properties of glutathione
Swiss Jim Lambert (SJL) mice lack of NK cells and NKT cells [115], and present lower levels of OPN in liver than B6 mice during APAP challenge [114]
Importantly, sensitivity analyses confirmed the robustness of the effects of weight and BMI, even after excluding lower-quality studies, whereas the effects of waist circumference did not remain significant in these analyses
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