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These agents activate the cAMP-PKA signaling cascade in pancreatic -cells 6 , resulting in glucose-dependent insulin secretion, suppression of pancreatic -cell glucagon release, and modulation of gastrointestinal motility through delayed gastric emptying 7

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The following are being older, because a person becomes less able to absorb B12 as they age eating a vegetarian or vegan diet taking anti-acid medication for an extended period weight loss surgery or other stomach surgery, which can affect how the digestive system absorbs vitamin B12 Most people can get enough vitamin B12 from dietary sources

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