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Thomas MC, Cooper ME
On April 30, 2026, the FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B outsourcing facility bulks list, finding no clinical need for large-scale compounding of these medications from bulk substances
Overall, these results are consistent with those observed in the SURPASS clinical trials, which were associated with low hypoglycemic risk despite robust glycemic control with tirzepatide
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