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They may be associated with a slightly increased risk of diabetic ketoacidosis, even in patients with normal glucose levels
Long-term safety data in humans is limited since it's used as a research compound
Dysfunctional telomeres can trigger the activation of p53, which in turn may inhibit the transcription of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which is the primary regulator of mitochondrial biogenesis and function
Modified disease activity scores that include twenty-eight-joint counts
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