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In regard to the unrefreshing sleep, we have already discussed the Hypothalamic-Pituitary-Adrenal Axis and the Hypocortisolism
There are concerns that drug could retrigger a restrictive eating disorder in someone diagnosed with one previously, or even trigger one in someone who hadnt had one before
GLP-1 agonists primarily influence insulin and satiety, while GIP (glucose-dependent insulinotropic polypeptide) affects fat metabolism
If the JCAs PICO-defined comparator doesnt match the trial design, the relative effectiveness assessment may be inconclusive or negative not because the drug doesnt work, but because the trial wasnt designed to answer the JCAs specific question
