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However, this evidence is limited, inconsistent, and does not demonstrate clinically significant effects comparable to prescription GLP-1 agonists

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Therefore, it is hypothesized that ghrelin synthesized within the hypothalamus, as opposed to gut-derived ghrelin, is the mediator of central orexigenic effects of ghrelin, although further research is needed 224

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Food and Drug Administration (FDA) has approved for treatment of obesity

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This study was also funded by the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine) (Grant No

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