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Summary: Results from retatrutide typically become meaningful from months 36, with Phase 2 trial data showing continued weight loss through 48 weeks at higher doses
Some people may simply experience decreased cravings, while others may experience strong food aversions, especially in the early phases of taking the medication
Make sure people get sufficient nutrition and are not losing too much muscle mass, Isaacs says
This response depends on SIRT1, which deacetylates FOXO3a and helps retain it within the nucleus, where it can activate genes related to angiogenesis
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