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In addition, those who regained more weight post-Zepbound had a more significant reversal of heart and metabolism benefits they achieved while on the drug including waist size, blood pressure, LDL cholesterol, and blood sugar levels than those who maintained their weight loss

Some of these same areas overlap with dopaminergic reward pathways, the brains pleasure circuits. In some individuals, this could dampen the usual reward response not just to food, but to other activities as well

You can read their plain-language overview of protein in diet