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The worst offenders are tilefish, swordfish, shark, king mackerel and bigeye tuna
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And the exogenous expression of Sam50 can reverse it and attenuate liver injury (95)
Overexpression of TFEB leads to degradation of bulk autophagic substrates such as damaged mitochondria (Nezich et al., 2015), long-lived protein aggregates (Martini-Stoica et al., 2016), and lipid droplets (Settembre et al., 2013), indicating the crucial role of TFEB in organelle-specific autophagy, such as mitophagy and lipophagy (Settembre et al., 2013
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