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Many GLP-1 medications (Ozempic, Mounjaro) were first approved for diabetes treatment, then later approved for obesity under different brand names (Wegovy, Zepbound)
Systematic reviews and meta-analyses suggest modest benefits for glycaemic control and lipid profiles in people with type 2 diabetes or metabolic syndrome, but the overall quality of evidence is considered moderate at best
All GLP-1 receptor agonist drugs, like semaglutide, slow down gastric emptying and reduce stomach acid production
Furthermore, the number of neuron-derived orphan receptor 1 (NOR1) which can modulate VSMC proliferation, is decreased by GLP-1RAs in a dose-dependent manner in mice [121]
