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The SUSTAIN 7 trial published in the BMJ found that participants taking 0.5 mg of semaglutide lost an average of about 10 pounds over 40 weeks

Room temperature storage can lead to faster degradation, reducing the drugs potency and effectiveness

For active individuals, an annual cardiovascular review that includes exercise tolerance assessment adds a useful data point

Phentermine works primarily by: Increasing noradrenaline release in the brain, which suppresses appetite Affecting central appetite regulation through the hypothalamus Reducing hunger signals through neurotransmitter effects Phentermine is typically prescribed for short-term use (usually 12 weeks or less) due to concerns about tolerance, dependence, and cardiovascular effects