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The study cannot establish whether adding MOTS-c to Mounjaro or Zepbound improves weight loss, insulin sensitivity, exercise capacity, or any other outcome, and it cannot quantify combination-specific adverse effects
The STEP trials (the major trials of semaglutide for weight management) included detailed monitoring of psychiatric symptoms
However, she cautions that these studies predominantly included white participants, and further research is needed to confirm similar benefits in other populations
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