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This article covers what tirzepatide is, how its dual agonist mechanism works, what clinical trials have shown, and how it compares to single-agonist peptides like semaglutide
The pivotal SURMOUNT-1 trial showed mean weight reductions of approximately 15.0% with the 5 mg dose, 19.5% with the 10 mg dose, and 20.9% with the 15 mg dose at 72 weeks, compared to 3.1% with placebo
The need for the medication to actively suppress appetite becomes less about fighting hunger and more about maintaining a new baseline
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