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doi: 10.26355/eurrev_202102_25077 223 TgelFWeissKYangYHuZZhangPWestenfelderC
Semaglutide treatment commenced at 0.25 mg per week for the initial 4 weeks using a pre-filled pen injector, with a fixed-dose escalation every 4 weeks until reaching the maintenance dose of 2.4 mg by week 16 (lower maintenance doses allowed if 2.4 mg was intolerable for participants)
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Clinical trials show berberine produces only modest weight reductions of approximately 2 to 4 kilograms, and many studies show little to no weight loss effect compared to the roughly 10 percent or greater body weight reduction seen with GLP-1 medications
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