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It is tempting to speculate that this apparent loss of benefit in patients with more advanced HF may be the result of increases in HR caused by activation of sinoatrial node (SAN) GLP-1Rs (64, 65), which could be mitigated with an agent such as GLP-1(2836) that retains cardiac and vascular protection of GLP-1, without activating the GLP-1R
Unfortunately, there are a number of additional side effects that the manufacturer failed to notify users of
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