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Preclinical research shows that GIP signaling: Promotes neuronal survival and reduces apoptosis (cell death) in the hippocampus, a brain region involved in pain memory and emotional processing of pain Enhances synaptic plasticity and BDNF expression, both of which are reduced in fibromyalgia Reduces oxidative stress in neural tissue by upregulating antioxidant enzymes These GIP-specific neuroprotective effects aren't available from GLP-1-only medications, giving tirzepatide a theoretical advantage for conditions involving neural dysfunction

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Observational evidence of neuroprotection with GLP-1 receptor agonists and SGLT-2 inhibitors Image content: This image is available to view online

Women who want to get pregnant should stop taking GLP-1 medications before trying to conceive