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This work has been widely read as evidence that neuroinflammation is a driver of neurodegeneration rather than merely a downstream marker, although that interpretation remains the subject of active investigation

Moreover, participants reported improvements in several obesity-related health markers, such as waist circumference, blood pressure, and quality of life measures

The primary outcomes were the percentage weight change and the proportion of participants losing at least 5% of their baseline weight, using treatment-policy estimand analysis (intention-to-treat principle)

Carrying significant extra weight increases the risk of type 2 diabetes, cardiovascular disease, and future pregnancy complications