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Large-scale lactylation histology studies confirm the presence of Kla in a large number of non-histone proteins, including NCL, YY1, and HMGB1, and these modifications regulate transcription, signal transduction, and ribosome assembly by altering protein conformation, charge distribution, and molecular interactions, thereby revealing the broad regulatory potential of lactate as a signaling molecule [78,79,80]
Furthermore, SARS-CoV-2 infection causes dysfunction of human SAN-like pacemaker cells and induces ferroptosis
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