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However, sustained high levels of circulating insulin may conversely exert a negative influence on cognitive function, due to prolonged peripheral hyperinsulinemia down-regulates insulin receptors at the blood-brain barrier (BBB) and reduces insulin transport into the brain, leading to brain insulin resistance (BIR) (1719)
PPAR activation by pioglitazone reduced cyclo-oxygenase 2 (COX2) expression in smooth muscle cells from hypertensive rats, and upregulated endogenous antioxidants Mn- and Cu/Zn-SOD [61]
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Soffer DE, Marston NA, Maki KC, et al
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