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Further studies have found that when intracellular iron and lipid disorders are disturbed, 15-hydroperoxy-arachidonoyl-phosphatidyl-ethyl amino alcohol (15-HpETE-PE) will accumulate, resulting in the appearance of ferroptosis [4, 34, 50], and one of the catalysts of this reaction may be the ALOX15 and scaffold protein PE-binding protein-1 (PEBP1) complex [51, 52], NO can inhibit the catalysis of this complex, thereby inhibiting ferroptosis

It sends signals from the mitochondria to the nucleus of the cell to regulate energy usage and metabolic function

Dig Dis Sci 31:103105 Florn C-H, Thesleff P, Nilsson (1987) Severe liver damage caused by therapeutic doses of acetaminophen