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In the latter assays, performed to measure internalization at earlier time-points, the modestly greater internalization originally seen with exendin-asp3 (Supplementary Fig

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Moreover, liraglutide trials in patients with HFrEF provided no clinical benefit, underscoring that the efficacy of incretin receptor agonism does not uniformly extend across heart-failure phenotypes and that remodelling mechanisms may differ by disease context [47]

10.1007/s00125-009-1611-5 Diabetologia 76 HsiehJ.LonguetC.MaidaA.BahramiJ.XuE.BakerC