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Their mechanisms enhance insulin sensitivity, reduce hepatic fat synthesis, improve lipid metabolism, and alleviate steatosis (Yabut and Drucker, 2023)

Although GLP-1RAs can reduce body weight by 15%25% in controlled settings, real-world adherence is limited, and nearly 70% of patients experience weight regain after discontinuation, raising the risk of long-term pharmacological dependence ( Looking ahead, the future of GLP-1based therapy will depend on addressing safety concerns, improving long-term adherence, and expanding clinical indications

Some apparent improvements were weak or affected by inadequate control groups