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At the same time, 4-OI promoted the osteogenic differentiation of BMSCs
Oral supplements typically take a few weeks of consistent, daily use to produce noticeable, gradual effects
Because tryptophan is an important carbon source, its extracellular degradation/ consumption imposes a metabolic challenge to both immune and tumor cells from the TME
Multiple trials indicated that it outperforms placebo, 379,380 whereas comparisons with acetazolamide have yielded contradictory results
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