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If a generic company files for Health Canada approval of a drug with patents listed on the Canadian Patent Register, they must serve the brand company with a Notice of Allegation that typically challenges the validity of the patent
Counselling and management strategies Management is best framed as treating the symptom syndrome while maintaining the metabolic benefits of therapy when safe
From this perspective, despite the exciting breakthrough in the hiPSC technique and the promising applications in the workings of BEC dysfunction in AD, validation of hiPSC-derived BECs in vitro models should be highly regarded to reflect the pathological process accurately (Lu et al., 2021a,b)
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