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To identify potential off-target substrates, we searched enriched motifs against the human proteome, using the enrichment score of the IL-1 motif (cleavage between Glu 18 and Asp 19) as the cutoff for predicted cleavage activity (Fig
A systematic review and meta-analysis of 12 randomised trials also suggests that ALC may reduce depressive symptoms with fewer adverse effects than established antidepressants
Goh said will worsen over time without treatment
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