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While measuring GH levels directly might seem like the best approach to assessing its function, the Insulin-like Growth Factor 1 (IGF-1) blood test is often preferred

However, most available randomized data derive from subgroup, post hoc, or exploratory analyses rather than trials specifically designed to evaluate dual therapy in HF populations

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But the FDA's briefing documents flagged it as an uncharacterized risk requiring further investigation before any approval, and researchers continue to weigh the angiogenic mechanism against the compound's apparent safety profile in animal models