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GLP-1R expression by immunohistochemical staining suggested that there was a marked increase in the expression in the PSCs, with activation (compare Figures 6a vs 6b)

[1] [2] The potential cardioprotective mechanisms of certain GLP-1 receptor agonists may involve improvements in glycemic control, weight reduction, blood pressure lowering, and possibly other effects on vascular function, though the exact mechanisms continue to be studied

Wat is oxidatieve stress

To evaluate the information content generated by the sequence design process, we calculated the entropy across each set of designed sequences, and the relative entropy (KullbackLeibler divergence, KL) between the distribution of amino acids at each sequence position estimated for the model-designed samples, and the training data