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A 2025 systematic review in the American Journal of Sports Medicine identified 544 articles published between 1993-2024, with 36 meeting inclusion criteria for their musculoskeletal focus alone
Diarrhea, vomiting, and decreased appetite round out the common GI effects
Additionally, biotin is believed to have anti-inflammatory effects, improve cognitive function, raise HDL (good) cholesterol and lower LDL (bad) cholesterol
Higher doses do not necessarily produce better results and may increase the risk of side effects like headaches or gastrointestinal discomfort without improving fat loss outcomes
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