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It can also appear in less obvious places, including the scalp, soles of the feet, palms, and under the nails

PMCID: PMC8615599

AKT1, also known as AKT kinase, is one of three closely related serine/threonine-protein kinases (AKT1, AKT2, and AKT3) and is expressed in insulin-sensitive tissues, such as the liver, skeletal muscles, and adipose tissue (Huang et al., 2018)

The new 5-HT hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression