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PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 78 H 123 N 23 O 23 S 2 Weight: 1,815.1 g/mol CAS: 221231-10-3 Origin: Residues 177-191 + N-terminal tyrosine Size: 16 amino acids Structure: Intramolecular disulfide bridge PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Readily soluble in water

K-means clustering was performed on the genera relative abundance data using the R script in the Supplementary Materials Scripts .zip file (KMScript), and clusters were plotted

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In most patients, the effectiveness of hormone therapy starts working in 1 or 2 weeks after receiving treatment