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The structural damage from freezing is not always visible, but it can reduce efficacy and potentially cause adverse reactions from aggregated proteins

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[1] [2] Patients should be counseled about the potential risk and instructed to report symptoms of thyroid tumors, including: A lump or swelling in the neck Hoarseness or voice changes Difficulty swallowing Shortness of breath It is important to note that the relevance of rodent C-cell tumor findings to humans remains uncertain

Since thirst signals are suppressed by the effects of these drugs, you may not know that youre in need of water and hydration before problems begin to develop