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This has always been part of how American medicine works, for semaglutide and for thousands of other drugs, particularly when a patient needs a formulation, strength, or delivery method that isn't available as a standard commercial product, or when the commercial product is priced out of reach for a large share of the population who could otherwise benefit from it
These findings are consistent with previously described pharmacodynamic differences between the two agents and may reflect differences in central appetite regulation and receptor binding characteristics
K.DeBose-BoydR
Teichman SL et al
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