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Oral Administration: Unlike other GLP-1 analogues that require weekly injections, Rybelsus can be taken orally, which may appeal to patients who prefer oral medications over injections
In Phase 2 trials, retatrutide produced average weight loss of up to 24% at the highest dose over 48 weeks substantially above tirzepatide's 2022% in equivalent trial conditions
The microdose row lists a lower initial exposure and gradual two to four week steps, with minimal early diarrhea but slower onset of efficacy as the trade-off
Those differences can affect the dose an individual needs, side effects, and the ease with sticking to the medication long term
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