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For context, the CSF exposure of monoclonal antibodies used in Alzheimers disease typically ranges from 0.1% to 0.3% of plasma concentrations, whereas small-molecule CNS drugs often exceed 5%, placing semaglutide within a low but pharmacologically plausible exposure range
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Across studies, tirzepatide has produced larger average weight reductions than semaglutide at commonly compared doses
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