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Peptides are naturally found in the human body
As a GLP-1 receptor agonist, it stimulates the pancreas to produce insulin when blood sugar is high and inhibits glucose release from the liver when levels are low helping maintain stable blood sugar levels essential for managing diabetes
For example, Bifidobacterium animalis F1-7 can upregulate acetylcarnitine levels in the gut, thereby downregulating the TLR4/NF-B pathway and reducing lipid accumulation and inflammation in foam cells, leading to a reduction in atherosclerotic plaque accumulation [129]
Both genetic circadian disruption and HFD feeding shifted adipocyte cell state from a pro-adipogenic signature towards an insulin resistant state 55,56
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