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Tsai and colleagues note that even though meds like Wegovy and Zepbound are effective in helping people shed pounds, the drugs' "high cost and high rates of gastrointestinal adverse effects can lead to treatment cessation and subsequent weight regain." Demand for weight-loss meds has also outstripped supply, so it's possible that the number of weight-loss surgery patients may rise again if "ongoing national shortages" of GLP-1s continue, the research team added

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Researchers should review available scientific literature, follow proper lab handling procedures, and use appropriate safety protocols when working with any peptide compound

Ipamorelin's pulsatile profile may better preserve normal GH axis feedback compared to sustained-release compounds