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This regulation was perturbed in glr1 cells, primarily because basal FDH3 mRNA levels were increased in the absence of stress, which was consistent with our previous observations (Fig 4)
For serious injuries or aggressive recovery goals, this efficiency may be important
The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds
The choice usually depends on tolerance, convenience, regulatory access, and cost not a clear human-efficacy ranking
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