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The FDA placed it in 503A Category 2 ("may present significant safety risks") in 2023, effectively barring compounding pharmacies from using it, then removed it from that category in April 2026 after nominators withdrew their submission, without adding it to the approved Category 1 compounding list

To meet demand, we hypothesize that EBNA2 and MYC highly induce one-carbon metabolism, which supports glutathione biosynthesis via the production of NADPH reducing units and the glycine building block

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Future research should focus on developing direct ERAD-targeting therapies and optimizing existing approaches to translate these findings into clinical applications