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Signs of Serious Issues Contact your doctor immediately if your fatigue is accompanied by any of the following "red flag" symptoms: Severe or persistent vomiting or diarrhoea Dizziness, light-headedness, or fainting A persistent rapid heart rate Confusion or difficulty concentrating Signs of severe dehydration (e.g., dark urine, no urination for 8+ hours) Medication Review Large-scale semaglutide trials show GI side effects (nausea, diarrhoea, vomiting, constipation) are most frequent in the first weeks post-injection but are usually mild and resolve with time and dietary management

10 Majority of patients had CVD and were receiving SOC 6,7,a 97% were receiving glucose-lowering medications 6 Patient characteristics at baseline (N=9650) 6,7 Select history of CVD at baseline (N=9650) 6 Select history of medication use at baseline (N=9650) 6,10 a Standard care consisted of glucose-lowering and cardiovascular riskreducing therapies administered in accordance with local guidelines

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