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Oral semaglutide (Rybelsus) requires specific administration instructions: it must be taken on an empty stomach before the first food, beverage, or other oral medications of the day, with no more than 4 ounces of plain water, and patients must wait at least 30 minutes before eating, drinking, or taking other medications

Known as a "triple G" agonist, it targets three receptors (GLP-1, GIP, and glucagon) to suppress appetite and increase energy expenditure

Research has found patients often preferred to avoid injectable medications in part due to embarrassment and inconvenience. Discretion is also important for patients

[1] [2] This secondary benefit can improve insulin sensitivity over time, further enhancing blood glucose control