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Results PQQ protects against myocardial hypertrophy and fibrosis in a TAC-induced mouse model system Initially, a C57BL/6 mouse model of myocardial hypertrophy was established by using previously published protocols to perform the TAC procedure, with a subset of these mice being treated using PQQ (Figure 1A)

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In addition to Keap1, Nrf2 is also directly targeted for proteasome-dependent degradation by a GSK3--TrCP-Cul1-mediated system 31,32,33,34

A B12 self-injection pen is available as an option for patients who prefer it over a traditional syringe