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After the plasma membrane carrier-mediated GSH release from the cell, GSH becomes accessible to the active site of - glutamyl transpeptidase, which catalyzes the breakdown of the GSH - glutamyl bond forming two fractions: The -glutamyl fraction and the cysteinyl-glycine by transferring the -glutamyl fraction to an amino acid acceptor, forming -glutamyl-amino acid
doi: 10.1007/978-1-4939-7649-2_27
and in muscle and adipose tissue, it may interfere with glucose and energy metabolism
This brings the ubiquitinproteasome system to the forefront as a target for drug discovery
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