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A variety of mechanisms contribute to this, some as simple as mechanical stress caused by additional weight, while others involve changes in hormones and metabolism
In this observational study, women who used HRT while taking tirzepatide: Lost nearly 19% of body weight on average Had a greater proportion achieving 20%, 25%, and even 30% total weight loss Showed improvements in heart- and metabolism-related lab measures, like blood pressure and triglycerides By contrast, women who took tirzepatide without HRT lost about 14% of their body weight on average in the same timeframe
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